T=remote_smtp defer (-53): retry time not reached for any host

chech your logs

cd /var/logs

then  more exim_mailing / grep email

you will get the error ,,,,,,,,,,,,,

then try to use the code below to fix the problem

This can be caused by multiple things, however if it happens for each email, it’s likely your exim databases are corrupt; to resolve this you should:

/usr/sbin/exim_tidydb -t 1d /var/spool/exim retry > /dev/null
/usr/sbin/exim_tidydb -t 1d /var/spool/exim reject > /dev/null
/usr/sbin/exim_tidydb -t 1d /var/spool/exim wait-remote_smtp > /dev/null

/scripts/courierup — force
/scripts/eximup –force

If you did that, yet the problem persists, you can either seek professional help, or contact the cPanel support.

References

http://forums.cpanel.net/f43/t-remote_smtp-defer-53-retry-time-not-reached-any-host-72383.html

OR  use below solutions

To solve this issue, you need to

1. Login to http://gmail.com with the account you use with exim4. It will ask you to login a second time with a captcha… do so


2. login on all of your machine that use this technique and issue the following command :sudo exim -qff

References

http://blog.mansonthomas.com/2009/04/send-mail-through-gmail-smtp-server.html

 

our ISP is likely blocking your connection via port 25:

[19:25:19 ns313489 root@4396451 ~]cPs# telnet mx1.cpanel.net 25
Trying 208.74.121.68...
telnet: connect to address 208.74.121.68: Connection timed out
[19:34:17 ns313489 root@4396451 ~]cPs# telnet mx2.cpanel.net 25
Trying 208.74.125.122...

[19:40:18 ns313489 root@4396451 ~]cPs# telnet mx1.hotmail.com 25
Trying 65.55.37.120...
telnet: connect to address 65.55.37.120: Connection timed out
Trying 65.55.92.152...
telnet: connect to address 65.55.92.152: Connection timed out


Whereas, it would normally work as such:

~ » telnet mx1.cpanel.net 25
Trying 208.74.121.68...
Connected to mx1.cpanel.net.
Escape character is '^]'.
220-mx1.cpanel.net ESMTP Exim 4.82 #2 Fri, 15 Nov 2013 12:33:33 -0600
220-We do not authorize the use of this system to transport unsolicited,
220 and/or bulk e-mail.
^]
telnet> quit
Connection closed.

~ » telnet mx1.hotmail.com 25
Trying 65.54.188.94...
Connected to mx1.hotmail.com.
Escape character is '^]'.
220 BAY0-MC2-F9.Bay0.hotmail.com Sending unsolicited commercial or bulk e-mail to Microsoft's computer network is prohibited. Other restrictions are found athttp://privacy.microsoft.com/en-us/anti-spam.mspx. Fri, 15 Nov 2013 10:47:53 -0800
^]
telnet> quit
Connection closed.

I would suggest contacting your provider to see if they have any restrictions on port 25.